Title: Human epileptic brain networks

Klaus Lehnertz

Short Abstract
The human brain is a complex network of interacting subsystems, and it is now commonly accepted that synchronization plays an important role in brain functioning and dysfunctioning. A prominent example for pathophysiologic neuronal synchronization is epilepsy along with its cardinal symptom, the epileptic seizure. Epilepsy affects approximately 1% of the world’s population, and in about 25% of individuals with epilepsy seizures cannot be controlled by any available therapy. Knowledge about mechanisms underlying generation, spread, and termination of the extreme event seizure in humans is still fragmentary. There is now growing evidence that an improved understanding of the epileptic process can be achieved through the analysis of interactions in large scale epileptic brain networks. I will present synchronization phenomena related to seizures in patients suffering from focal drug-resistant epilepsies and will discuss their impact for the development of new therapeutic possibilities based on seizure prediction.